The PDZ Protein GIPC Regulates Trafficking of the LPA(1) Receptor from APPL Signaling Endosomes and Attenuates the Cell’s Response to LPA

Lysophosphatidic acid (LPA) mediates diverse cellular responses through the activation of at least six LPA receptors – LPA(1–6,) but the interacting proteins and signaling pathways that mediate the specificity of these receptors are largely unknown. We noticed that LPA(1) contains a PDZ binding moti...

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Bibliografiske detaljer
Main Authors: Varsano, Tal, Taupin, Vanessa, Guo, Lixia, Baterina, Oscar Y., Farquhar, Marilyn G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493537/
https://ncbi.nlm.nih.gov/pubmed/23145131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049227
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