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The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

Secretory polymorphic serine/threonine kinases control pathogenesis of Toxoplasma gondii in the mouse. Genetic studies show that the pseudokinase ROP5 is essential for acute virulence, but do not reveal its mechanism of action. Here we demonstrate that ROP5 controls virulence by blocking IFN-γ media...

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Bibliografiske detaljer
Main Authors: Behnke, Michael S., Fentress, Sarah J., Mashayekhi, Mona, Li, Lucy X., Taylor, Gregory A., Sibley, L. David
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493473/
https://ncbi.nlm.nih.gov/pubmed/23144612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002992
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