The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

Secretory polymorphic serine/threonine kinases control pathogenesis of Toxoplasma gondii in the mouse. Genetic studies show that the pseudokinase ROP5 is essential for acute virulence, but do not reveal its mechanism of action. Here we demonstrate that ROP5 controls virulence by blocking IFN-γ media...

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Detaylı Bibliyografya
Asıl Yazarlar: Behnke, Michael S., Fentress, Sarah J., Mashayekhi, Mona, Li, Lucy X., Taylor, Gregory A., Sibley, L. David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493473/
https://ncbi.nlm.nih.gov/pubmed/23144612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002992
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