Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification

Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage specification function through active modification of the chromatin landscape and establishment of new e...

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Detalhes bibliográficos
Main Authors: Samstein, Robert M., Arvey, Aaron, Josefowicz, Steven Z., Peng, Xiao, Reynolds, Alex, Sandstrom, Richard, Neph, Shane, Sabo, Peter, Kim, Jeong M., Liao, Will, O. Li, Ming, Leslie, Christina, Stamatoyannopoulos, John A., Rudensky, Alexander Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493256/
https://ncbi.nlm.nih.gov/pubmed/23021222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.053
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