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Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict
Regulatory T (Treg) cells, whose differentiation and function are controlled by X-chromosome-encoded transcription factor Foxp3, are generated in the thymus (tTreg) and extrathymically (peripheral, pTreg) and their deficiency results in fatal autoimmunity. Here we demonstrate that a Foxp3 enhancer,...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3422629/ https://ncbi.nlm.nih.gov/pubmed/22770213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.05.031 |
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