Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia

D-type cyclins form complexes with cyclin dependent kinases (CDK4/6), and promote cell cycle progression. Although cyclin D functions appear largely tissue specific, we demonstrate that cyclin D3 has unique functions in lymphocyte development and cannot be replaced by cyclin D2, which is also expres...

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Bibliografiske detaljer
Main Authors: Sawai, Catherine, Freund, Jacquelyn, Oh, Philmo, Ndiaye-Lobry, Delphine, Bretz, Jamieson C., Strikoudis, Alexandros, Genesca, Lali, Trimarchi, Thomas, Kelliher, Michelle A., Clark, Marcus, Soulier, Jean, Chen-Kiang, Selina, Aifantis, Iannis
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493168/
https://ncbi.nlm.nih.gov/pubmed/23079656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.09.016
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