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Cooperative Anti-Invasive Effect of Cdc42/Rac1 Activation and ROCK Inhibition in SW620 Colorectal Cancer Cells with Elevated Blebbing Activity

Rho GTPases are key regulators of tumour cell invasion and therefore constitute attractive targets for the design of anticancer agents. Several strategies have been developed to modulate their increased activities during cancer progression. Interestingly, none of these approaches took into account t...

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Main Authors: de Toledo, Marion, Anguille, Christelle, Roger, Laureline, Roux, Pierre, Gadea, Gilles
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492328/
https://ncbi.nlm.nih.gov/pubmed/23144867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048344
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