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Loss of p53 promotes RhoA–ROCK-dependent cell migration and invasion in 3D matrices
In addition to its role in controlling cell cycle progression, the tumor suppressor protein p53 can also affect other cellular functions such as cell migration. In this study, we show that p53 deficiency in mouse embryonic fibroblasts cultured in three-dimensional matrices induces a switch from an e...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064414/ https://ncbi.nlm.nih.gov/pubmed/17606864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200701120 |
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