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Loss of p53 promotes RhoA–ROCK-dependent cell migration and invasion in 3D matrices

In addition to its role in controlling cell cycle progression, the tumor suppressor protein p53 can also affect other cellular functions such as cell migration. In this study, we show that p53 deficiency in mouse embryonic fibroblasts cultured in three-dimensional matrices induces a switch from an e...

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Bibliografiske detaljer
Main Authors: Gadea, Gilles, de Toledo, Marion, Anguille, Christelle, Roux, Pierre
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064414/
https://ncbi.nlm.nih.gov/pubmed/17606864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200701120
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