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Loss of p53 promotes RhoA–ROCK-dependent cell migration and invasion in 3D matrices

In addition to its role in controlling cell cycle progression, the tumor suppressor protein p53 can also affect other cellular functions such as cell migration. In this study, we show that p53 deficiency in mouse embryonic fibroblasts cultured in three-dimensional matrices induces a switch from an e...

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Autors principals: Gadea, Gilles, de Toledo, Marion, Anguille, Christelle, Roux, Pierre
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064414/
https://ncbi.nlm.nih.gov/pubmed/17606864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200701120
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