Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated with Decreased Bdnf

Multiple mechanisms likely contribute to neuronal death in Parkinson’s disease (PD), including mitochondrial dysfunction and oxidative stress. Peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1α) positively regulates the expression of genes required for mitochondrial biogen...

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Detalhes bibliográficos
Main Authors: Clark, Joanne, Silvaggi, Jessica M., Kiselak, Tomas, Zheng, Kangni, Clore, Elizabeth L., Dai, Ying, Bass, Caroline E., Simon, David K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492133/
https://ncbi.nlm.nih.gov/pubmed/23145024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048925
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