MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation

Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the α-synuclein (α-syn) gene. Mutant α-syn expression increases the vulnerability of neurons to exogenous insults. In this study, we developed a new PD model in the transgenic mice expressing mutant hemizygo...

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Bibliografiska uppgifter
I publikationen:Korean J Physiol Pharmacol
Huvudupphovsmän: Lee, Seongmi, Oh, Seung Tack, Jeong, Ha Jin, Pak, Sok Cheon, Park, Hi-Joon, Kim, Jongpil, Cho, Hyun-seok, Jeon, Songhee
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Korean Physiological Society and The Korean Society of Pharmacology 2017
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709479/
https://ncbi.nlm.nih.gov/pubmed/29200905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2017.21.6.625
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