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MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation
Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the α-synuclein (α-syn) gene. Mutant α-syn expression increases the vulnerability of neurons to exogenous insults. In this study, we developed a new PD model in the transgenic mice expressing mutant hemizygo...
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| 出版年: | Korean J Physiol Pharmacol |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Korean Physiological Society and The Korean Society of Pharmacology
2017
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5709479/ https://ncbi.nlm.nih.gov/pubmed/29200905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2017.21.6.625 |
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