Frequent Emergence of N348I in HIV-1 Subtype C Reverse Transcriptase with Failure of Initial Therapy Reduces Susceptibility to Reverse-Transcriptase Inhibitors

Background. It is not known how often mutations in the connection and ribonuclease H domains of reverse transcriptase (RT) emerge with failure of first-line antiretroviral therapy (ART) in subtype C human immunodeficiency virus type 1 (HIV-1) infection and how these mutations affect susceptibility t...

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Detalhes bibliográficos
Main Authors: Brehm, Jessica H., Koontz, Dianna L., Wallis, Carole L., Shutt, Kathleen A., Sanne, Ian, Wood, Robin, McIntyre, James A., Stevens, Wendy S., Sluis-Cremer, Nicolas, Mellors, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
HIV/AIDS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491849/
https://ncbi.nlm.nih.gov/pubmed/22618567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/cis501
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