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Exosomes from IDO(+) DC are therapeutic in CIA and DTH disease models

OBJECTIVE: We have demonstrated previously that dendritic cells (DC), modified with immunosuppressive cytokines, and exosomes derived from the DC can suppress the onset of murine CIA and reduce the severity of established arthritis. Indoleamine 2,3-dioxygenase (IDO) is a tryptophan degrading enzyme...

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Bibliografski detalji
Glavni autori: Bianco, Nicole R., Kim, Seon Hee, Ruffner, Melanie A., Robbins, Paul D.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491653/
https://ncbi.nlm.nih.gov/pubmed/19180475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24229
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