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Fragment-guided design of subnanomolar β-lactamase inhibitors active in vivo
Fragment-based design was used to guide derivatization of a lead series of β-lactamase inhibitors that had heretofore resisted optimization for in vivo activity. X-ray structures of fragments overlaid with the lead suggested new, unanticipated functionality and points of attachment. Synthesis of thr...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3491531/ https://ncbi.nlm.nih.gov/pubmed/23043117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208337109 |
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