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Structure-based optimization of Cephalothin-analogue boronic acids as β-lactamase inhibitors
Boronic acids have proved to be promising selective inhibitors of β-lactamases, acting as transition state analogues. Starting from a previously described nanomolar inhibitor of AmpC β-lactamase, three new inhibitors were designed to gain interactions with highly conserved residues, such as Asn343,...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2396669/ https://ncbi.nlm.nih.gov/pubmed/17997318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.10.075 |
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