Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns

BACKGROUND: Aberrant CpG island promoter DNA hypermethylation is frequently observed in cancer and is believed to contribute to tumor progression by silencing the expression of tumor suppressor genes. Previously, we observed that promoter hypermethylation in breast cancer reflects cell lineage rathe...

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Autors principals: Sproul, Duncan, Kitchen, Robert R, Nestor, Colm E, Dixon, J Michael, Sims, Andrew H, Harrison, David J, Ramsahoye, Bernard H, Meehan, Richard R
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491412/
https://ncbi.nlm.nih.gov/pubmed/23034185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2012-13-10-r84
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