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Genomic insights into cancer-associated aberrant CpG island hypermethylation

Carcinogenesis is thought to occur through a combination of mutational and epimutational events that disrupt key pathways regulating cellular growth and division. The DNA methylomes of cancer cells can exhibit two striking differences from normal cells; a global reduction of DNA methylation levels a...

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Detalhes bibliográficos
Main Authors: Sproul, Duncan, Meehan, Richard R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662888/
https://ncbi.nlm.nih.gov/pubmed/23341493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bfgp/els063
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