Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns

BACKGROUND: Aberrant CpG island promoter DNA hypermethylation is frequently observed in cancer and is believed to contribute to tumor progression by silencing the expression of tumor suppressor genes. Previously, we observed that promoter hypermethylation in breast cancer reflects cell lineage rathe...

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Sonraí Bibleagrafaíochta
Main Authors: Sproul, Duncan, Kitchen, Robert R, Nestor, Colm E, Dixon, J Michael, Sims, Andrew H, Harrison, David J, Ramsahoye, Bernard H, Meehan, Richard R
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2012
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491412/
https://ncbi.nlm.nih.gov/pubmed/23034185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2012-13-10-r84
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