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Deoxynucleoside [1-thio]triphosphates prevent proofreading during in vitro DNA synthesis.

The contribution of proofreading to the fidelity of catalysis by DNA polymerases has been determined with deoxyribonucleoside [1-thio]triphosphate substrates. These analogues, which contain a sulfur in place of an oxygen on the alpha phosphorus, are incorporated into DNA by DNA polymerases at rates...

詳細記述

保存先:
書誌詳細
主要な著者: Kunkel, T A, Eckstein, F, Mildvan, A S, Koplitz, R M, Loeb, L A
フォーマット: Artigo
言語:Inglês
出版事項: 1981
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC349124/
https://ncbi.nlm.nih.gov/pubmed/6458818
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