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Chromosome cohesion decreases in human eggs with advanced maternal age

Aneuploidy in human eggs increases with maternal age and can result in infertility, miscarriages, and birth defects. The molecular mechanisms leading to aneuploidy, however, are largely unknown especially in the human where eggs are exceedingly rare and precious. We obtained human eggs from subjects...

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Autors principals: Duncan, Francesca E., Hornick, Jessica E., Lampson, Michael A., Schultz, Richard M., Shea, Lonnie D., Woodruff, Teresa K.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491123/
https://ncbi.nlm.nih.gov/pubmed/22823533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2012.00866.x
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