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Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes

Aneuploidy arising early in development is the leading genetic cause of birth defects and developmental disabilities in humans. Most errors in chromosome number originate from the egg, and maternal age is well established as the key risk factor. Although the importance of this problem for reproducti...

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Bibliographic Details
Main Authors: Chiang, Teresa, Duncan, Francesca E., Schindler, Karen, Schultz, Richard M., Lampson, Michael A.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939204/
https://ncbi.nlm.nih.gov/pubmed/20817534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.06.069
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