Elevated intracellular pH appears in aged oocytes and causes oocyte aneuploidy associated with the loss of cohesion in mice

Increases in the aneuploidy rate caused by the deterioration of cohesion with increasing maternal age have been well documented. However, the molecular mechanism for the loss of cohesion in aged oocytes remains unknown. In this study, we found that intracellular pH (pH(i)) was elevated in aged oocyt...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Cheng, Jin-Mei, Li, Jian, Tang, Ji-Xin, Chen, Su-Ren, Deng, Shou-Long, Jin, Cheng, Zhang, Yan, Wang, Xiu-Xia, Zhou, Chen-Xi, Liu, Yi-Xun
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026820/
https://ncbi.nlm.nih.gov/pubmed/27472084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1201255
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