Elevated intracellular pH appears in aged oocytes and causes oocyte aneuploidy associated with the loss of cohesion in mice

Increases in the aneuploidy rate caused by the deterioration of cohesion with increasing maternal age have been well documented. However, the molecular mechanism for the loss of cohesion in aged oocytes remains unknown. In this study, we found that intracellular pH (pH(i)) was elevated in aged oocyt...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Cheng, Jin-Mei, Li, Jian, Tang, Ji-Xin, Chen, Su-Ren, Deng, Shou-Long, Jin, Cheng, Zhang, Yan, Wang, Xiu-Xia, Zhou, Chen-Xi, Liu, Yi-Xun
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026820/
https://ncbi.nlm.nih.gov/pubmed/27472084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1201255
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