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Evidence That a Defective Spindle Assembly Checkpoint Is Not the Primary Cause of Maternal Age-Associated Aneuploidy in Mouse Eggs
Advanced maternal age is unequivocally associated with increased aneuploidy in human eggs and infertility, but the molecular basis for this phenomenon is unknown. An age-dependent deterioration of the spindle assembly checkpoint (SAC) has been proposed as a probable cause of aneuploidy. Accurate chr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for the Study of Reproduction, Inc.
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2754889/ https://ncbi.nlm.nih.gov/pubmed/19553597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.109.077909 |
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