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Evidence That a Defective Spindle Assembly Checkpoint Is Not the Primary Cause of Maternal Age-Associated Aneuploidy in Mouse Eggs

Advanced maternal age is unequivocally associated with increased aneuploidy in human eggs and infertility, but the molecular basis for this phenomenon is unknown. An age-dependent deterioration of the spindle assembly checkpoint (SAC) has been proposed as a probable cause of aneuploidy. Accurate chr...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Duncan, Francesca E., Chiang, Teresa, Schultz, Richard M., Lampson, Michael A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Society for the Study of Reproduction, Inc. 2009
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754889/
https://ncbi.nlm.nih.gov/pubmed/19553597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.109.077909
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