Age-associated alterations in the micromechanical properties of chromosomes in the mammalian egg

PURPOSE: The incidence of aneuploidy in eggs from women of advanced reproductive age can exceed 60 %, making the mammalian egg a unique model system to study the mechanisms of chromosome segregation errors. METHODS: Here we applied a novel biophysical chromosome stretching approach to quantify mecha...

Full description

Saved in:
Bibliographic Details
Published in:J Assist Reprod Genet
Main Authors: Hornick, Jessica E., Duncan, Francesca E., Sun, Mingxuan, Kawamura, Ryo, Marko, John F., Woodruff, Teresa K.
Format: Artigo
Language:Inglês
Published: Springer US 2015
Subjects:
Gamete Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429432/
https://ncbi.nlm.nih.gov/pubmed/25758987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-015-0453-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items