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Age-associated alterations in the micromechanical properties of chromosomes in the mammalian egg

PURPOSE: The incidence of aneuploidy in eggs from women of advanced reproductive age can exceed 60 %, making the mammalian egg a unique model system to study the mechanisms of chromosome segregation errors. METHODS: Here we applied a novel biophysical chromosome stretching approach to quantify mecha...

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Bibliografski detalji
Izdano u:J Assist Reprod Genet
Glavni autori: Hornick, Jessica E., Duncan, Francesca E., Sun, Mingxuan, Kawamura, Ryo, Marko, John F., Woodruff, Teresa K.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429432/
https://ncbi.nlm.nih.gov/pubmed/25758987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-015-0453-y
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