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Bim dictates naïve CD4 T cell lifespan and the development of age-associated functional defects()
With age peripheral naïve CD4 T cells become both longer-lived and functionally impaired and they express reduced levels of Bim, a pro-apoptotic Bcl-family member. In this study, we show that reduced Bim expression by naïve CD4 T cells intrinsically mediates their longer lifespan in the periphery. M...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3490203/ https://ncbi.nlm.nih.gov/pubmed/20844198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001668 |
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