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CD4 T cell Defects in the Aged: Causes, Consequences and Strategies to Circumvent

Aging leads to reduced immunity, especially adaptive responses. A key deficiency is the poor ability to mount robust antibody response. Although intrinsic alterations in B cells with age are in part responsible, impaired CD4 T cell help makes a major contribution to the poor antibody response. Other...

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Detalhes bibliográficos
Main Authors: Zhang, Wenliang, Brahmakshatriya, Vinayak, Swain, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989398/
https://ncbi.nlm.nih.gov/pubmed/24440384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2014.01.002
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