Bcl6 Controls the Th2 Inflammatory Activity of Regulatory T Cells by Repressing Gata3 Function

The transcriptional repressor Bcl6 is a critical arbiter of T helper cell fate, promoting the follicular helper (Tfh) lineage while repressing other T helper cell lineages. Bcl6-deficient (Bcl6-/-) mice develop a spontaneous and severe Th2-type inflammatory disease, thus warranting assessment of Bcl...

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Bibliografiske detaljer
Main Authors: Sawant, Deepali V., Sehra, Sarita, Nguyen, Evelyn T., Jadhav, Rohit, Englert, Kate, Shinnakasu, Ryo, Hangoc, Giao, Broxmeyer, Hal E., Nakayama, Toshinori, Perumal, Narayanan B., Kaplan, Mark H., Dent, Alexander L.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490013/
https://ncbi.nlm.nih.gov/pubmed/23053511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201794
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