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Agonist-promoted Lys 63-linked polyubiquitination of the human kappa opioid receptor is involved in receptor down-regulation

Ubiquitination of the human κ opioid receptor (hKOR) expressed in CHO cells was observed in the presence of the proteasomal inhibitor MG132 and enhanced by the agonists U50,488H and dynorphin A (Dyn A). The dominant negative (DN) mutants GRK2-K220R and β-arrestin (319–418), but not dynamin I-K44A, r...

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Bibliografiske detaljer
Main Authors: Li, Jian-Guo, Haines, Dale S., Liu-Chen, Lee-Yuan
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489932/
https://ncbi.nlm.nih.gov/pubmed/18212250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.107.042846
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