TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis

The engagement of Toll-like receptor 3 (TLR3) leads to the oligomerization of the adaptor TICAM-1 (TRIF), which can induces either of three acute cellular responses, namely, cell survival coupled to Type I interferon production, or cell death, via apoptosis or necrosis. The specific response elicite...

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Bibliographic Details
Main Authors: Seya, Tsukasa, Shime, Hiroaki, Takaki, Hiromi, Azuma, Masahiro, Oshiumi, Hiroyuki, Matsumoto, Misako
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489747/
https://ncbi.nlm.nih.gov/pubmed/23162759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.21244
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