Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8α(+) dendritic cells

PolyI:C is a nucleotide pattern molecule that induces cross-presentation of foreign Ag in myeloid dendritic cells (DC) and MHC Class I-dependent proliferation of cytotoxic T lymphocytes (CTL). DC (BM or spleen CD8α(+)) have sensors for dsRNA including polyI:C to signal facilitating cross-presentatio...

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Bibliographic Details
Main Authors: Azuma, Masahiro, Ebihara, Takashi, Oshiumi, Hiroyuki, Matsumoto, Misako, Seya, Tsukasa
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429562/
https://ncbi.nlm.nih.gov/pubmed/22934250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.19893
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