The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc(Min/+) mice

BACKGROUND: Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc (Min/+) mice. Microbiota also contains double-stranded RNA (dsRNA), a ligand for TLR3, which activates the toll-like receptor ada...

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Detalhes bibliográficos
Publicado no:J Biomed Sci
Main Authors: Ono, Junya, Shime, Hiroaki, Takaki, Hiromi, Takashima, Ken, Funami, Kenji, Yoshida, Sumito, Takeda, Yohei, Matsumoto, Misako, Kasahara, Masanori, Seya, Tsukasa
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5646017/
https://ncbi.nlm.nih.gov/pubmed/29041928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-017-0387-z
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