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Sigma-1 Receptor Agonists Directly Inhibit Na(V)1.2/1.4 Channels
(+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors. (+)-SKF 10047 inhibits K(+), Na(+) and Ca2+ channels via sigma-1 receptor activation. We found that (+)-SKF 10047 inhibited Na(V)1.2...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3489664/ https://ncbi.nlm.nih.gov/pubmed/23139844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049384 |
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