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Lubiprostone Activates CFTR, but not ClC-2, via the Prostaglandin Receptor (EP(4))

The goal of this study was to determine the mechanism of lubiprostone activation of epithelial chloride transport. Lubiprostone is a bicyclic fatty acid approved for the treatment of constipation [1]. There is uncertainty, however, as to how lubiprostone increases epithelial chloride transport. Dire...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Norimatsu, Yohei, Moran, Aurelia R., MacDonald, Kelvin D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489164/
https://ncbi.nlm.nih.gov/pubmed/22960173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.08.097
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