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Methadone but not Morphine Inhibits Lubiprostone-Stimulated Cl(−) Currents in T84 Intestinal Cells and Recombinant Human ClC-2, but not CFTR Cl(−) Currents
In clinical trials, methadone, but not morphine, appeared to prevent beneficial effects of lubiprostone, a ClC-2 Cl(−) channel activator, on opioid-induced constipation. Effects of methadone and morphine on lubiprostone-stimulated Cl(−) currents were measured by short circuit current (Isc) across T8...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer-Verlag
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3627040/ https://ncbi.nlm.nih.gov/pubmed/22918821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12013-012-9406-6 |
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