Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors

BACKGROUND: Linaclotide has been proposed as a treatment for the same gastrointestinal indications for which lubiprostone has been approved, chronic idiopathic constipation and irritable bowel syndrome with constipation. Stressors damage the epithelial cell barrier and cellular homeostasis leading t...

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Autors principals: Cuppoletti, John, Blikslager, Anthony T, Chakrabarti, Jayati, Nighot, Prashant K, Malinowska, Danuta H
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403872/
https://ncbi.nlm.nih.gov/pubmed/22553939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-12-3
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