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Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37
The intracellular location of nucleic acid sensors prevents recognition of extracellular self-DNA released by dying cells. However, on forming a complex with the endogenous antimicrobial peptide LL37, extracellular DNA is transported into endosomal compartments of plasmacytoid dendritic cells, leadi...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488884/ https://ncbi.nlm.nih.gov/pubmed/22927244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-401364 |
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