Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37

The intracellular location of nucleic acid sensors prevents recognition of extracellular self-DNA released by dying cells. However, on forming a complex with the endogenous antimicrobial peptide LL37, extracellular DNA is transported into endosomal compartments of plasmacytoid dendritic cells, leadi...

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Detalhes bibliográficos
Main Authors: Chamilos, Georgios, Gregorio, Josh, Meller, Stephan, Lande, Roberto, Kontoyiannis, Dimitrios P., Modlin, Robert L., Gilliet, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488884/
https://ncbi.nlm.nih.gov/pubmed/22927244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-401364
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