Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

Dendritic cell (DC) responses to extracellular self-DNA and self-RNA are prevented by the endosomal seclusion of nucleic acid–recognizing Toll-like receptors (TLRs). In psoriasis, however, plasmacytoid DCs (pDCs) sense self-DNA that is transported to endosomal TLR9 upon forming a complex with the an...

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Main Authors: Ganguly, Dipyaman, Chamilos, Georgios, Lande, Roberto, Gregorio, Josh, Meller, Stephan, Facchinetti, Valeria, Homey, Bernhard, Barrat, Franck J., Zal, Tomasz, Gilliet, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737167/
https://ncbi.nlm.nih.gov/pubmed/19703986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090480
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