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Regulation of CD38 Expression in Human Airway Smooth Muscle Cells: Role of Class I Phosphatidylinositol 3 Kinases
The ADP-ribosyl cyclase activity of CD38 generates cyclic ADP-ribose, a Ca(2+)–mobilizing agent. In human airway smooth muscle (HASM) cells, TNF-α mediates CD38 expression through mitogen-activated protein kinases and NF-κB and AP-1. The phosphatidylinositol-3 kinase/Akt (PI3K/Akt) pathway is involv...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Thoracic Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488627/ https://ncbi.nlm.nih.gov/pubmed/22556157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0025OC |
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