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Metallation and mismetallation of iron and manganese proteins in vitro and in vivo: the class I ribonucleotide reductases as a case study

How cells ensure correct metallation of a given protein and whether a degree of promiscuity in metal binding has evolved are largely unanswered questions. In a classic case, iron- and manganese-dependent superoxide dismutases (SODs) catalyze the disproportionation of superoxide using highly similar...

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Bibliographische Detailangaben
Hauptverfasser: Cotruvo, Joseph A., Stubbe, JoAnne
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488304/
https://ncbi.nlm.nih.gov/pubmed/22991063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2mt20142a
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