UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages

UVA (320–400 nm) represents the main spectral component of solar UV radiation, induces pre-mutagenic DNA lesions and is classified as Class I carcinogen. Recently, discussion arose whether UVA induces DNA double-strand breaks (dsbs). Only few reports link the induction of dsbs to UVA exposure and th...

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Bibliographic Details
Main Authors: Greinert, R., Volkmer, B., Henning, S., Breitbart, E. W., Greulich, K. O., Cardoso, M. C., Rapp, Alexander
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488256/
https://ncbi.nlm.nih.gov/pubmed/22941639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks824
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