Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage

Ionising radiation induces clustered DNA damage sites which pose a severe challenge to the cell’s repair machinery, particularly base excision repair. To date, most studies have focussed on two-lesion clusters. We have designed synthetic oligonucleotides to give a variety of three-lesion clusters co...

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Bibliographic Details
Main Authors: Eccles, Laura J., Lomax, Martine E., O’Neill, Peter
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831305/
https://ncbi.nlm.nih.gov/pubmed/19965771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1070
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