Increased mutability and decreased repairability of a three-lesion clustered DNA-damaged site comprised of an AP site and bi-stranded 8-oxoG lesions

PURPOSE: Ionizing radiation induces DNA damage, some of which are present in clusters, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. These clusters are thought to contribute to the detrimental effects of radiation, in part due to the co...

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Autores principales: Cunniffe, Siobhan, Walker, Alexandra, Stabler, Robert, O’Neill, Peter, Lomax, Martine E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Informa Healthcare 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059193/
https://ncbi.nlm.nih.gov/pubmed/24597750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/09553002.2014.899449
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