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Mechanisms for Kinase-mediated Dimerization of the Epidermal Growth Factor Receptor
We study a mechanism by which dimerization of the EGF receptor (EGFR) cytoplasmic domain is transmitted to the ectodomain. Therapeutic and other small molecule antagonists to the kinase domain that stabilize its active conformation, but not those that stabilize an inactive conformation, stabilize ec...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488093/ https://ncbi.nlm.nih.gov/pubmed/22988250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.414391 |
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