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Mechanisms for Kinase-mediated Dimerization of the Epidermal Growth Factor Receptor

We study a mechanism by which dimerization of the EGF receptor (EGFR) cytoplasmic domain is transmitted to the ectodomain. Therapeutic and other small molecule antagonists to the kinase domain that stabilize its active conformation, but not those that stabilize an inactive conformation, stabilize ec...

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Detalhes bibliográficos
Main Authors: Lu, Chafen, Mi, Li-Zhi, Schürpf, Thomas, Walz, Thomas, Springer, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488093/
https://ncbi.nlm.nih.gov/pubmed/22988250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.414391
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