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A role for the 2′ OH of peptidyl-tRNA substrate in peptide release on the ribosome revealed through RF-mediated rescue

The 2′ OH of the peptidyl-tRNA substrate is thought to be important for catalysis of both peptide bond formation and peptide release in the ribosomal active site. The release reaction also specifically depends on a release factor protein (RF) to hydrolyze the ester linkage of the peptidyl-tRNA upon...

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書誌詳細
主要な著者: Shaw, Jeffrey J., Trobro, Stefan, He, Shan L., Åqvist, Johan, Green, Rachel
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487719/
https://ncbi.nlm.nih.gov/pubmed/22921065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.06.011
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